Physical activation of innate immunity by spiky particles.
Identifieur interne : 000973 ( Main/Exploration ); précédent : 000972; suivant : 000974Physical activation of innate immunity by spiky particles.
Auteurs : Ji Wang [République populaire de Chine] ; Hui-Jiuan Chen [République populaire de Chine] ; Tian Hang [République populaire de Chine] ; Yang Yu [États-Unis] ; Guishi Liu [République populaire de Chine] ; Gen He [République populaire de Chine] ; Shuai Xiao [République populaire de Chine] ; Bo-Ru Yang [République populaire de Chine] ; Chengduan Yang [République populaire de Chine] ; Fanmao Liu [République populaire de Chine] ; Jun Tao [République populaire de Chine] ; Mei X. Wu [États-Unis] ; Xi Xie [République populaire de Chine]Source :
- Nature nanotechnology [ 1748-3395 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux, Cellules dendritiques (anatomopathologie), Cellules dendritiques (immunologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (anatomopathologie), Infections à Orthomyxoviridae (immunologie), Lipide A (analogues et dérivés), Lipide A (pharmacologie), Macrophages (anatomopathologie), Macrophages (immunologie), Nanoparticules (), Nanoparticules (usage thérapeutique), Phagocytose (), Souris, Souris knockout, Titane (), Titane (pharmacologie), Tumeurs expérimentales (), Tumeurs expérimentales (anatomopathologie), Tumeurs expérimentales (immunologie), Virus de la grippe A (immunologie).
- MESH :
- analogues et dérivés : Lipide A.
- anatomopathologie : Cellules dendritiques, Infections à Orthomyxoviridae, Macrophages, Tumeurs expérimentales.
- immunologie : Cellules dendritiques, Infections à Orthomyxoviridae, Macrophages, Tumeurs expérimentales, Virus de la grippe A.
- pharmacologie : Lipide A, Titane.
- usage thérapeutique : Nanoparticules.
- Animaux, Infections à Orthomyxoviridae, Nanoparticules, Phagocytose, Souris, Souris knockout, Titane, Tumeurs expérimentales.
English descriptors
- KwdEn :
- Animals, Dendritic Cells (immunology), Dendritic Cells (pathology), Influenza A virus (immunology), Lipid A (analogs & derivatives), Lipid A (pharmacology), Macrophages (immunology), Macrophages (pathology), Mice, Mice, Knockout, Nanoparticles (chemistry), Nanoparticles (therapeutic use), Neoplasms, Experimental (immunology), Neoplasms, Experimental (pathology), Neoplasms, Experimental (therapy), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (pathology), Orthomyxoviridae Infections (therapy), Phagocytosis (drug effects), Titanium (chemistry), Titanium (pharmacology).
- MESH :
- chemical , analogs & derivatives : Lipid A.
- chemistry : Nanoparticles, Titanium.
- drug effects : Phagocytosis.
- immunology : Dendritic Cells, Influenza A virus, Macrophages, Neoplasms, Experimental, Orthomyxoviridae Infections.
- pathology : Dendritic Cells, Macrophages, Neoplasms, Experimental, Orthomyxoviridae Infections.
- chemical , pharmacology : Lipid A, Titanium.
- therapeutic use : Nanoparticles.
- therapy : Neoplasms, Experimental, Orthomyxoviridae Infections.
- Animals, Mice, Mice, Knockout.
Abstract
Microbial biochemicals have been indicated as the primary stimulators of innate immunity, the first line of the body's defence against infections. However, the influence of topological features on a microbe's surface on immune responses remains largely unknown. Here we demonstrate the ability of TiO2 microparticles decorated with nanospikes (spiky particles) to activate and amplify the immune response in vitro and in vivo. The nanospikes exert mechanical stress on the cells, which results in potassium efflux and inflammasome activation in macrophages and dendritic cells during phagocytosis. The spiky particles augment antigen-specific humoral and cellular immune responses in the presence of monophosphoryl lipid A and elicit protective immunity against tumour growth and influenza viral infection. The study offers insights into how surface physical cues can tune the activation of innate immunity and provides a basis for engineering particles with increased immunogenicity and adjuvanticity.
DOI: 10.1038/s41565-018-0274-0
PubMed: 30374159
Affiliations:
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Le document en format XML
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</affiliation>
</author>
<author><name sortKey="Xie, Xi" sort="Xie, Xi" uniqKey="Xie X" first="Xi" last="Xie">Xi Xie</name>
<affiliation wicri:level="3"><nlm:affiliation>State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Guangdong Province Key Laboratory of Display Material and Technology, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou, China. xiexi27@mail.sysu.edu.cn.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Guangdong Province Key Laboratory of Display Material and Technology, The First Affiliated Hospital of Sun Yat-Sen University, Sun Yat-Sen University, Guangzhou</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature nanotechnology</title>
<idno type="eISSN">1748-3395</idno>
<imprint><date when="2018" type="published">2018</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Dendritic Cells (immunology)</term>
<term>Dendritic Cells (pathology)</term>
<term>Influenza A virus (immunology)</term>
<term>Lipid A (analogs & derivatives)</term>
<term>Lipid A (pharmacology)</term>
<term>Macrophages (immunology)</term>
<term>Macrophages (pathology)</term>
<term>Mice</term>
<term>Mice, Knockout</term>
<term>Nanoparticles (chemistry)</term>
<term>Nanoparticles (therapeutic use)</term>
<term>Neoplasms, Experimental (immunology)</term>
<term>Neoplasms, Experimental (pathology)</term>
<term>Neoplasms, Experimental (therapy)</term>
<term>Orthomyxoviridae Infections (immunology)</term>
<term>Orthomyxoviridae Infections (pathology)</term>
<term>Orthomyxoviridae Infections (therapy)</term>
<term>Phagocytosis (drug effects)</term>
<term>Titanium (chemistry)</term>
<term>Titanium (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules dendritiques (anatomopathologie)</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Infections à Orthomyxoviridae ()</term>
<term>Infections à Orthomyxoviridae (anatomopathologie)</term>
<term>Infections à Orthomyxoviridae (immunologie)</term>
<term>Lipide A (analogues et dérivés)</term>
<term>Lipide A (pharmacologie)</term>
<term>Macrophages (anatomopathologie)</term>
<term>Macrophages (immunologie)</term>
<term>Nanoparticules ()</term>
<term>Nanoparticules (usage thérapeutique)</term>
<term>Phagocytose ()</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Titane ()</term>
<term>Titane (pharmacologie)</term>
<term>Tumeurs expérimentales ()</term>
<term>Tumeurs expérimentales (anatomopathologie)</term>
<term>Tumeurs expérimentales (immunologie)</term>
<term>Virus de la grippe A (immunologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Lipid A</term>
</keywords>
<keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Lipide A</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cellules dendritiques</term>
<term>Infections à Orthomyxoviridae</term>
<term>Macrophages</term>
<term>Tumeurs expérimentales</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term>
<term>Titanium</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Phagocytosis</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules dendritiques</term>
<term>Infections à Orthomyxoviridae</term>
<term>Macrophages</term>
<term>Tumeurs expérimentales</term>
<term>Virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dendritic Cells</term>
<term>Influenza A virus</term>
<term>Macrophages</term>
<term>Neoplasms, Experimental</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dendritic Cells</term>
<term>Macrophages</term>
<term>Neoplasms, Experimental</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Lipide A</term>
<term>Titane</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Lipid A</term>
<term>Titanium</term>
</keywords>
<keywords scheme="MESH" qualifier="therapeutic use" xml:lang="en"><term>Nanoparticles</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Neoplasms, Experimental</term>
<term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Nanoparticules</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Mice</term>
<term>Mice, Knockout</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Infections à Orthomyxoviridae</term>
<term>Nanoparticules</term>
<term>Phagocytose</term>
<term>Souris</term>
<term>Souris knockout</term>
<term>Titane</term>
<term>Tumeurs expérimentales</term>
</keywords>
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</teiHeader>
<front><div type="abstract" xml:lang="en">Microbial biochemicals have been indicated as the primary stimulators of innate immunity, the first line of the body's defence against infections. However, the influence of topological features on a microbe's surface on immune responses remains largely unknown. Here we demonstrate the ability of TiO<sub>2</sub>
microparticles decorated with nanospikes (spiky particles) to activate and amplify the immune response in vitro and in vivo. The nanospikes exert mechanical stress on the cells, which results in potassium efflux and inflammasome activation in macrophages and dendritic cells during phagocytosis. The spiky particles augment antigen-specific humoral and cellular immune responses in the presence of monophosphoryl lipid A and elicit protective immunity against tumour growth and influenza viral infection. The study offers insights into how surface physical cues can tune the activation of innate immunity and provides a basis for engineering particles with increased immunogenicity and adjuvanticity.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<region><li>Guangdong</li>
<li>Massachusetts</li>
</region>
<settlement><li>Jiangmen</li>
</settlement>
</list>
<tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Wang, Ji" sort="Wang, Ji" uniqKey="Wang J" first="Ji" last="Wang">Ji Wang</name>
</region>
<name sortKey="Chen, Hui Jiuan" sort="Chen, Hui Jiuan" uniqKey="Chen H" first="Hui-Jiuan" last="Chen">Hui-Jiuan Chen</name>
<name sortKey="Hang, Tian" sort="Hang, Tian" uniqKey="Hang T" first="Tian" last="Hang">Tian Hang</name>
<name sortKey="He, Gen" sort="He, Gen" uniqKey="He G" first="Gen" last="He">Gen He</name>
<name sortKey="Liu, Fanmao" sort="Liu, Fanmao" uniqKey="Liu F" first="Fanmao" last="Liu">Fanmao Liu</name>
<name sortKey="Liu, Guishi" sort="Liu, Guishi" uniqKey="Liu G" first="Guishi" last="Liu">Guishi Liu</name>
<name sortKey="Tao, Jun" sort="Tao, Jun" uniqKey="Tao J" first="Jun" last="Tao">Jun Tao</name>
<name sortKey="Xiao, Shuai" sort="Xiao, Shuai" uniqKey="Xiao S" first="Shuai" last="Xiao">Shuai Xiao</name>
<name sortKey="Xie, Xi" sort="Xie, Xi" uniqKey="Xie X" first="Xi" last="Xie">Xi Xie</name>
<name sortKey="Yang, Bo Ru" sort="Yang, Bo Ru" uniqKey="Yang B" first="Bo-Ru" last="Yang">Bo-Ru Yang</name>
<name sortKey="Yang, Chengduan" sort="Yang, Chengduan" uniqKey="Yang C" first="Chengduan" last="Yang">Chengduan Yang</name>
</country>
<country name="États-Unis"><region name="Massachusetts"><name sortKey="Yu, Yang" sort="Yu, Yang" uniqKey="Yu Y" first="Yang" last="Yu">Yang Yu</name>
</region>
<name sortKey="Wu, Mei X" sort="Wu, Mei X" uniqKey="Wu M" first="Mei X" last="Wu">Mei X. Wu</name>
</country>
</tree>
</affiliations>
</record>
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